Publikationen


2024

On dementia, duties, and daughters. An ethical analysis of healthcare professionals being confronted with conflicts regarding filial duties in informal dementia care.(link is external)

Dogan V, Taneska M, Novotni G, Iloski S, Novotni A, Dimitrova V, Milutinovic M, Novotni L, Weber A, Joksimkoski B, Chorbev I, Hasani S, Ivanovska A, Grimmer T, Fischer J. Front. Psychiatry. 2024 Oct 01. https://doi.org/10.3389/fpsyt.2024.1421582.​​​​​​​


Progress in the Treatment of Alzheimer's Disease Is Needed - Position Statement of European Alzheimer's Disease Consortium (EADC) Investigators.(link is external)

Jessen F, Kramberger MG, Angioni D, Aarsland D, Balasa M, Bennys M, Boada M, Boban M, Chincarini A, Exalto L, Felbecker A, Fliessbach K, Frisoni GB, Garza-Martinez AJ, Grimmer T, Hanseeuw B, Hort J, Ivanoiu A, Klöppel S, Krajcovicova L, McGuinnes B, Mecocci P, de Mendonca A, Nous A, Ousset P-J, Paquet C, Perneczky R, Peters O, Tabuas-Pereira M, Piazza F, Plantone D, Riverol M, Ruiz A, Sacco G, Santana I, Scarmeas N, Solje E, Stefanova E, Sutovsky S, van der Flier W, Welsh T, Wimo A, Winblad B, Frölich L & Engelborghs S. J Prev Alzheimers Dis. 2024 Aug 11. https://doi.org/10.14283/jpad.2024.153.


Gehirn-Check-Up: strukturiertes Vorgehen zur Diagnostik von kognitiven Störungen im hausärztlichen Setting. (link is external)

Wolski L, Bopp AK, Schwientek AK, Langer S, Dogan V & Grimmer T. Z Gerontol Geriat. 2024 Jun 05. https://doi.org/10.1007/s00391-024-02319-y.


Telefonische Hilfe zur Selbsthilfe: Das Alzheimer-Telefon aus der Sicht der Nutzer:innen(link is external)

Kurz A, Fischer IM, Dogan V, Kurz C. GMS Ger Med Sci. 2024 Apr 24 doi: 10.3205/000331.


North Macedonia interprofessional dementia care (NOMAD) - personalized care plans for people with dementia and caregiver psychoeducation delivered at home by interprofessional teams(link is external)

Novotni G, Taneska M, Novotni A, Fischer J, Iloski S, Ivanovska A, Dimitrova V, Novotni L, Milutinovic M, Joksimoski B, Chorbev I, Hasani S, Dogan V, Grimmer T, Kurz A. Front. Dement. 2024 Apr 10 doi: 10.3389/frdem.2024.1391471.


2023

Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease(link is external)

Bateman RJ, Smith J, Donohue MC, [...] Grimmer T, [...] GRADUATE I and II Investigators and the
Gantenerumab Study Group. Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease. N Engl J Med. 2023 Nov 16;389(20):1862-1876. doi: 10.1056/NEJMoa2304430. PMID: 37966285; PMCID: PMC10794000.


Comparison of diagnostic routines for suspected Alzheimer's disease patients in US-American and German primary care(link is external)

Menne F, Grimmer T, Schipke CG. Neurodegener Dis Manag. 2023 Oct;13(5):269-280. doi: 10.2217/nmt-2023-0023. Epub 2023 Dec 8. PMID: 38063885.


Automated antigen assays display a high heterogeneity for the detection of SARS-
CoV-2 variants of concern, including several Omicron sublineages(link is external)

Osterman A, Krenn F, Iglhaut M,[...] Grimmer T, Durner J, Czibere L, Dächert C, Grzimek-Koschewa N, Protzer U, Kaderali L, Baldauf HM, Keppler OT. Med Microbiol Immunol. 2023 Oct;212(5):307-322. doi: 10.1007/s00430-023-00774-9. Epub 2023 Aug 10. PMID: 37561226; PMCID: PMC10501957.


Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies(link is external)

Finze A, Biechele G, Rauchmann BS, [...] Goldhardt O, Grimmer T [...] Levin J, Perneczky R, Brendel M. Mol Psychiatry. 2023 Oct;28(10):4438-4450. doi: 10.1038/s41380-023-02188-8. Epub 2023 Jul 26. PMID: 37495886; PMCID: PMC10827660.


Irrelevant interests? A qualitative study into how German family surrogates of persons living with dementia fulfill their legal role as advocates of an advance directive(link is external)

Fischer J, Roßmeier C, Hartmann J, Riedl L, Tensil M, Diehl-Schmid J, Jox RJ. The Gerontologist, gnad119. 2023 Aug. doi: 10.1093/geront/gnad119.


Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease(link is external)

European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration; Luo J, Thomassen JQ, Bellenguez C, [....] Grimmer T [...]  Ramirez A, Lambert JC, Frikke-Schmidt R.
JAMA Netw Open. 2023 May 1;6(5):e2313734. doi: 10.1001/jamanetworkopen.2023.13734.
Erratum in: JAMA Netw Open. 2023 Jun 1;6(6):e2321189. doi: 10.1001/jamanetworkopen.2023.21189. PMID: 37195665; PMCID: PMC10193187.


Anti-amyloid antibody therapies in Alzheimer's disease(link is external)

Perneczky R, Jessen F, Grimmer T, Levin J, Flöel A, Peters O, Froelich L. Brain. 2023 Mar
1;146(3):842-849. doi: 10.1093/brain/awad005. PMID: 36655336.


Disease specific and nonspecific metabolic brain networks in behavioral variant of frontotemporal
dementia(link is external)

Rus T, Perovnik M, Vo A, Nguyen N, Tang C, Jamšek J, Šurlan Popović K, Grimmer T, Yakushev I, Diehl-Schmid J, Eidelberg D, Trošt M. Hum Brain Mapp. 2023 Feb 15;44(3):1079-1093. doi: 10.1002/hbm.26140. Epub 2022 Nov 5. PMID: 36334269; PMCID: PMC9875921.


Consortium for the Harmonization of Neuropsychological Assessment. Feasibility of a standard
cognitive assessment in European academic memory clinics(link is external)

Grazia A, Altomare D, Preis L, Monsch AU, Cappa SF, Gauthier S, Frölich L, Winblad B, Welsh-Bohmer KA, Teipel SJ, Boccardi M; . Alzheimers Dement.
2023 Jun;19(6):2276-2286. doi: 10.1002/alz.12830. Epub 2022 Dec 1. Erratum in:
Alzheimers Dement. 2024 Jan;20(1):752. doi: 10.1002/alz.13531. PMID: 36453876.


2022

Herpes simplex virus alters Alzheimer´s disease biomarkers - A hypothesis paper(link is external)

Goldhardt O, Freiberger R, Dreyer T, Wilner L, Yakushev I, Ortner M, Förstl H, Diehl-Schmid J, Milz E,  Priller J, Ramirez A, Magdolen V, Thaler M, Grimmer T.                        Alheimers Dement. 2022 Nov 17 doi: 10.1002/alz.12834.   

Cognitive impairment and microvascular function in end-stage renal disease. (link is external)

Angermann S, Günthner R, Hanssen H, Lorenz G, Braunisch MC, Steubl D, Matschkal J, Kemmner S, Hausinger R, Block Z, Haller B, Heemann U, Kotliar K, Grimmer T, Schmaderer C. Int J Methods Psychiatr Res. 2022 Mar 15:e1909. doi: 10.1002/mpr.1909. Online ahead of print. PMID: 35290686

Mapping covariance in brain FDG uptake to structural connectivity. (link is external)

Yakushev I, Ripp I, Wang M, Savio A, Schutte M, Lizarraga A, Bogdanovic B, Diehl-Schmid J, Hedderich DM, Grimmer T, Shi K. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1288-1297. doi: 10.1007/s00259-021-05590-y. Epub 2021 Oct 22. PMID: 34677627 Free PMC article.

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum. (link is external)

Jansen WJ, Janssen O, Tijms BM, Vos SJB, Ossenkoppele R, [...] Grimmer T et al. JAMA Neurol. 2022 Mar 1;79(3):228-243. doi: 10.1001/jamaneurol.2021.5216. PMID: 35099509

Decoupling of regional neural activity and inter-regional functional connectivity in Alzheimer's disease: a simultaneous PET/MR study. (link is external)

Maleki Balajoo S, Rahmani F, Khosrowabadi R, Meng C, Eickhoff SB, Grimmer T, Zarei M, Drzezga A, Sorg C, Tahmasian M. Eur J Nucl Med Mol Imaging. 2022 Feb 24. doi: 10.1007/s00259-022-05692-1. Online ahead of print. PMID: 35199225

2021

Neuronavigated repetitive transcranial magnetic stimulation as novel mapping technique provides insights into language function in primary progressive aphasia. (link is external)

Mueller-Sarnowski F, Sollmann N, Schröder A, Houri L, Ille S, Grimmer T, Krieg SM, Diehl-Schmid J. Brain Imaging Behav. 2021 Dec 28. doi: 10.1007/s11682-021-00605-6.    Online ahead of print. PMID: 34964088

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. (link is external)

de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, [...] Grimmer T, et al.. Nat Commun. 2021 Jun 7;12(1):3417. doi: 10.1038/s41467-021-22491-8. PMID: 34099642 Free PMC article.

Intepirdine as adjunctive therapy to donepezil for mild-to-moderate Alzheimer's disease: A randomized, placebo-controlled, phase 3 clinical trial (MINDSET). (link is external)

Lang FM, Mo Y, Sabbagh M, Solomon P, Boada M, Jones RW, Frisoni GB, Grimmer T, Dubois B, Harnett M, Friedhoff SR, Coslett S, Cummings JL. Alzheimers Dement (N Y). 2021 May 31;7(1):e12136. doi: 10.1002/trc2.12136. eCollection 2021. PMID: 34095437 Free PMC article.

Age-Dependency of Total Tau in the Cerebrospinal Fluid Is Corrected by Amyloid-β 1-40: A Correlational Study in Healthy Adults. (link is external)

Zebhauser PT, Berthele A, Franz MS, Goldhardt O, Diehl-Schmid J, Priller J, Ortner M, Grimmer T. J Alzheimers Dis. 2021;83(1):155-162. doi: 10.3233/JAD-210286. PMID: 34250938

2020

European Academy of Neurology/European Alzheimer's Disease Consortium position statement on diagnostic disclosure, biomarker counseling, and management of patients with mild cognitive impairment. (link is external)

Frederiksen KS, Nielsen TR, Winblad B, Schmidt R, Kramberger MG, Jones RW, Hort J, Grimmer T, Georges J, Frölich L, Engelborghs S, Dubois B, Waldemar G. Eur J Neurol. 2021 Jul;28(7):2147-2155. doi: 10.1111/ene.14668. Epub 2020 Dec 23. PMID: 33368924 Free PMC article.

Biomarker counseling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer's disease consortium survey. (link is external)

Frederiksen KS, Nielsen TR, Appollonio I, Andersen BB, [...] Grimmer T et al. Int J Geriatr Psychiatry. 2021 Feb;36(2):324-333. doi: 10.1002/gps.5427. Epub 2020 Sep 16. PMID: 32896040

Biomarker Testing: Piercing the Fog of Alzheimer's and Related Dementia. (link is external)

Horgan D, Nobili F, Teunissen C, Grimmer T, Mitrecic D, Ris L, Pirtosek Z, Bernini C, Federico A, Blackburn D, Logroscino G, Scarmeas N. Biomed Hub. 2020 Nov 23;5(3):19-40. doi: 10.1159/000511233. eCollection 2020 Sep-Dec. PMID: 33564663 Free PMC article.

Value of a Panel of 6 Serum Biomarkers to Differentiate Between Healthy Controls and Mild Cognitive Impairment Due to Alzheimer Disease. (link is external)

Schipke CG, Menne F, Rubow S, Sigle JP, Peters O, Grimmer T. Alzheimer Dis Assoc Disord. 2020 Oct-Dec;34(4):318-324. doi: 10.1097/WAD.0000000000000397. PMID: 32649324

Correction:18F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases. (link is external)

Grimmer T, Shi K, Diehl-Schmid J, Natale B, Drzezga A, Förster S, Förstl H, Schwaiger M, Yakushev I, Wester HJ, Kurz A, Yousefi BH. Mol Psychiatry. 2020 Oct;25(10):2643. doi: 10.1038/s41380-018-0302-3. PMID: 30464328 Free PMC article.

Integrity of Neurocognitive Networks in Dementing Disorders as Measured with Simultaneous PET/Functional MRI. (link is external)

Ripp I, Stadhouders T, Savio A, Goldhardt O, Cabello J, Calhoun V, Riedl V, Hedderich D, Diehl-Schmid J, Grimmer T, Yakushev I. J Nucl Med. 2020 Sep;61(9):1341-1347. doi: 10.2967/jnumed.119.234930. Epub 2020 May 1. PMID: 32358091 Free article.

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. (link is external)

Saddiki H, Fayosse A, Cognat E, Sabia S, Engelborghs S, [...] Grimmer T et al. J. PLoS Med. 2020 Aug 20;17(8):e1003289. doi: 10.1371/journal.pmed.1003289. eCollection 2020 Aug. PMID: 32817639 Free PMC article.

Regional Cerebral Associations Between Psychometric Tests and Imaging Biomarkers in Alzheimer's Disease. (link is external)

Hedderich DM, Drost R, Goldhardt O, Ortner M, Müller-Sarnowski F, Diehl-Schmid J, Zimmer C, Förstl H, Yakushev I, Jahn T, Grimmer T. Front Psychiatry. 2020 Aug 13;11:793. doi: 10.3389/fpsyt.2020.00793. eCollection 2020. PMID: 32903760 Free PMC article.

Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil. (link is external)

Ortner M, Stange M, Schneider H, Schröder C, Buerger K, Müller C, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Grimmer T, Steimer W. Drug Des Devel Ther. 2020 Aug 11;14:3251-3262. doi: 10.2147/DDDT.S247259. eCollection 2020. PMID: 32848364 Free PMC article.

Variability of clinical syndromes and cerebral glucose metabolism in symptomatic frontotemporal lobar degeneration associated with progranulin mutations. (link is external)

Licata A, Grimmer T, Winkelmann J, Wagner M, Goldhardt O, Riedl L, Roßmeier C, Yakushev I, Diehl-Schmid J. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Aug;21(5-6):389-395. doi: 10.1080/21678421.2020.1779302. Epub 2020 Jun 22. PMID: 32567375

Serum Concentrations of Cholinesterase Inhibitors in Patients With Alzheimer's Dementia Are Frequently Below the Recommended Levels. (link is external)

Ortner M, Stange M, Schneider H, Schroeder C, Buerger K, Müller C, Dorn B, Goldhardt O, Diehl-Schmid J, Förstl H, Steimer W, Grimmer T. Front Pharmacol. 2020 May 21;11:691. doi: 10.3389/fphar.2020.00691. eCollection 2020. PMID: 32508640 Free PMC article.

The overnight reduction of amyloid β 1-42 plasma levels is diminished by the extent of sleep fragmentation, sAPP-β, and APOE ε4 in psychiatrists on call. (link is external)

Grimmer T, Laub T, Hapfelmeier A, Eisele T, Fatke B, Hölzle P, Lüscher S, Parchmann AM, Rentrop M, Schwerthöffer D, Müller-Sarnowski F, Ortner M, Goldhardt O, Kurz A, Förstl H, Alexopoulos P. Alzheimers Dement. 2020 May;16(5):759-769. doi: 10.1002/alz.12072. Epub 2020 Apr 8. PMID: 32270596

Different CSF protein profiles in amyotrophic lateral sclerosis and frontotemporal dementia with C9orf72 hexanucleotide repeat expansion. (link is external)

Barschke P, Oeckl P, Steinacker P, Al Shweiki MR, Weishaupt JH, Landwehrmeyer GB, Anderl-Straub S, Weydt P, Diehl-Schmid J, Danek A, Kornhuber J, Schroeter ML, Prudlo J, Jahn H, Fassbender K, Lauer M, van der Ende EL, van Swieten JC, Volk AE, Ludolph AC, Otto M; German FTLD consortium. J Neurol Neurosurg Psychiatry. 2020 May;91(5):503-511. doi: 10.1136/jnnp-2019-322476. Epub 2020 Mar 4. PMID: 32132225

Normative brain volume reports may improve differential diagnosis of dementing neurodegenerative diseases in clinical practice. (link is external)

Hedderich DM, Dieckmeyer M, Andrisan T, Ortner M, Grundl L, Schön S, Suppa P, Finck T, Kreiser K, Zimmer C, Yakushev I, Grimmer T. Eur Radiol. 2020 May;30(5):2821-2829. doi: 10.1007/s00330-019-06602-0. Epub 2020 Jan 30. PMID: 32002640

Targeted Mass Spectrometry Suggests Beta-Synuclein as Synaptic Blood Marker in Alzheimer's Disease. (link is external)

Oeckl P, Halbgebauer S, Anderl-Straub S, von Arnim CAF, Diehl-Schmid J, Froelich L, Grimmer T, Hausner L, Denk J, Jahn H, Steinacker P, Weishaupt JH, Ludolph AC, Otto M. J Proteome Res. 2020 Mar 6;19(3):1310-1318. doi: 10.1021/acs.jproteome.9b00824. Epub 2020 Feb 26. PMID: 32101007

Correction to: Amyloid PET, FDG-PET or MRI? - the power of different imaging biomarkers to detect progression of early Alzheimer's disease. (link is external)

Ortner M, Drost R, Hedderich D, Goldhardt O, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Yakushev I, Grimmer T. BMC Neurol. 2020 Mar 5;20(1):80. doi: 10.1186/s12883-020-01649-9. PMID: 32138693 Free PMC article.

2019

Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease-A simultaneous resting-state FDG-PET/fMRI study. (link is external)

Scherr M, Utz L, Tahmasian M, Pasquini L, Grothe MJ, Rauschecker JP, Grimmer T, Drzezga A, Sorg C, Riedl V. Hum Brain Mapp. 2021 Sep;42(13):4134-4143. doi: 10.1002/hbm.24517. Epub 2019 Jan 30. PMID: 30697878 Free PMC article.

Amyloid PET, FDG-PET or MRI? - the power of different imaging biomarkers to detect progression of early Alzheimer's disease. (link is external)

Ortner M, Drost R, Hedderich D, Goldhardt O, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Yakushev I, Grimmer T. BMC Neurol. 2019 Oct 31;19(1):264. doi: 10.1186/s12883-019-1498-9. PMID: 31672138 Free PMC article.

Prognostic value of Alzheimer's biomarkers in mild cognitive impairment: the effect of age at onset. (link is external)

Altomare D, Ferrari C, Caroli A, Galluzzi S, Prestia A,[...] Grimmer T et al. Alzheimer’s Disease Neuroimaging Initiative. J Neurol. 2019 Oct;266(10):2535-2545. doi: 10.1007/s00415-019-09441-7. Epub 2019 Jul 2. PMID: 31267207

Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia. (link is external)

Meeter LHH, Steketee RME, Salkovic D, Vos ME, [...] Grimmer T, Goldhardt O et al. J Neurol Neurosurg Psychiatry. 2019 Sep;90(9):997-1004. doi: 10.1136/jnnp-2018-319784. Epub 2019 May 23. PMID: 31123142 Free PMC article.

Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer's disease and associated with CSF-TAU and FDG-PET. (link is external)

Goldhardt O, Warnhoff I, Yakushev I, Begcevic I, Förstl H, Magdolen V, Soosaipillai A, Diamandis E, Alexopoulos P, Grimmer T. Transl Neurodegener. 2019 Aug 27;8:25. doi: 10.1186/s40035-019-0168-6. eCollection 2019. PMID: 31467673 Free PMC article.

Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer's disease.(link is external)

Göttler J, Preibisch C, Riederer I, Pasquini L, Alexopoulos P, Bohn KP, Yakushev I, Beller E, Kaczmarz S, Zimmer C, Grimmer T, Drzezga A, Sorg C. J Cereb Blood Flow Metab. 2019 Jul;39(7):1314-1325. doi: 10.1177/0271678X18759182. Epub 2018 Feb 12. PMID: 29431005 Free PMC article.

An augmented reality approach for ADL support in Alzheimer's disease: a crossover trial. (link is external)

Rohrbach N, Gulde P, Armstrong AR, Hartig L, Abdelrazeq A, Schröder S, Neuse J, Grimmer T, Diehl-Schmid J, Hermsdörfer J. J Neuroeng Rehabil. 2019 Jun 3;16(1):66. doi: 10.1186/s12984-019-0530-z. PMID: 31159816 Free PMC article. Clinical Trial.

FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations. (link is external)

Diehl-Schmid J, Licata A, Goldhardt O, Förstl H, Yakushew I, Otto M, Anderl-Straub S, Beer A, Ludolph AC, Landwehrmeyer GB, Levin J, Danek A, Fliessbach K, Spottke A,  Fassbender K, Lyros E, Prudlo J, Krause BJ, Volk A, Edbauer D, Schroeter ML, Drzezga A, Kornhuber J, Lauer M; FTLDc Study Group, Grimmer T. Transl Psychiatry. 2019 Jan 31;9(1):54. doi: 10.1038/s41398-019-0381-1. PMID: 30705258 Free PMC article.

Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease. (link is external)

Grimmer T, Goldhardt O, Yakushev I, Ortner M, Sorg C, Diehl-Schmid J, Förstl H, Kurz A, Perneczky R, Miners S. Neurodegener Dis. 2019;19(1):43-50. doi: 10.1159/000500811. Epub 2019 Jul 2. PMID: 31266021

Plasma Levels of Soluble AβPPβ as a Biomarker for Alzheimer's Disease with Dementia. (link is external)

Alexopoulos P, Thierjung N, Economou P, Werle L, Buhl F, Kagerbauer S, Papanastasiou AD, Grimmer T, Gourzis P, Berthele A, Hemmer B, Kübler H, Martin J, Politis A,          Perneczky R. J Alzheimers Dis. 2019;69(1):83-90. doi: 10.3233/JAD-181088. PMID: 30909232

Decreased Vascular Pulsatility in Alzheimer's Disease Dementia Measured by Transcranial Color-Coded Duplex Sonography. (link is external)

Ortner M, Hauser C, Schmaderer C, Muggenthaler C, Hapfelmeier A, Sorg C, Diehl-Schmid J, Kurz A, Förstl H, Ikenberg B, Kotliar K, Poppert H, Grimmer T. Neuropsychiatr Dis Treat. 2019 Dec 20;15:3487-3499. doi: 10.2147/NDT.S225754. eCollection 2019. PMID: 31908463 Free PMC article.

Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment. (link is external)

Oeckl P, Halbgebauer S, Anderl-Straub S, Steinacker P, Huss AM, Neugebauer H, von Arnim CAF, Diehl-Schmid J, Grimmer T, Kornhuber J, Lewczuk P, Danek A; Consortium for Frontotemporal Lobar Degeneration German, Ludolph AC, Otto M. J Alzheimers Dis. 2019;67(2):481-488. doi: 10.3233/JAD-180325. PMID: 30594925

2018

18F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases. (link is external)

Grimmer T, Shi K, Diehl-Schmid J, Natale B, Drzezga A, Förster S, Förstl H, Schwaiger M, Yakushev I, Wester HJ, Kurz A, Yousefi BH. Mol Psychiatry. 2020 Oct;25(10):2608-2619. doi: 10.1038/s41380-018-0203-5. Epub 2018 Aug 17. PMID: 30120417 Free PMC article.

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. (link is external)

Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, Glaab E, Bobbili DR, Antony P, Koegelsberger S, Kurz A, Grimmer T, Morgan K, Vardarajan BN, Reitz C, Hardy J, Bras J, Guerreiro R, Balling R, Schneider JG, Riemenschneider M; AESG. Mol Psychiatry. 2020 Mar;25(3):629-639. doi: 10.1038/s41380-018-0091-8. Epub 2018 Jul 9. PMID: 29988083 Free PMC article

Functional Decline in Alzheimer's Disease: A Continuum. (link is external)

Grimmer T, Licata A. J Am Geriatr Soc. 2018 Dec;66(12):2239-2240. doi: 10.1111/jgs.15668. Epub 2018 Nov 21. PMID: 30462834 No abstract available.

Rate of β-amyloid accumulation varies with baseline amyloid burden: Implications for anti-amyloid drug trials. (link is external)

Guo T, Dukart J, Brendel M, Rominger A, Grimmer T, Yakushev I; Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement. 2018 Nov;14(11):1387-1396. doi: 10.1016/j.jalz.2018.05.013. Epub 2018 Jul 4. PMID: 30420035

Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia. (link is external)

Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, [...] Diehl-Schmid J, Grimmer T et al. Ann Neurol. 2018 Nov;84(5):729-740. doi: 10.1002/ana.25333. PMID: 30255971 Free PMC article.

Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study. (link is external)

Scheltens P, Hallikainen M, Grimmer T, Duning T, Gouw AA, Teunissen CE, Wink AM, Maruff P, Harrison J, van Baal CM, Bruins S, Lues I, Prins ND. Alzheimers Res Ther. 2018 Oct 12;10(1):107. doi: 10.1186/s13195-018-0431-6. PMID: 30309389 Free PMC article. Clinical Trial

Serum neurofilament light chain in behavioral variant frontotemporal dementia. (link is external)

Steinacker P, Anderl-Straub S, Diehl-Schmid J, [...] Grimmer T et al. Neurology. 2018 Oct 9;91(15):e1390-e1401. doi: 10.1212/WNL.0000000000006318. Epub 2018 Sep 12. PMID: 30209235

A multivariate metabolic imaging marker for behavioral variant frontotemporal dementia. (link is external)

Nazem A, Tang CC, Spetsieris P, Dresel C, Gordon ML, Diehl-Schmid J, Grimmer T, Yakushev I, Mattis PJ, Ma Y, Dhawan V, Eidelberg D. Alzheimers Dement (Amst). 2018 Aug 29;10:583-594. doi: 10.1016/j.dadm.2018.07.009. eCollection 2018. PMID: 30417069 Free PMC article.

An Explorative Note on Apraxia Tests. (link is external)

Gulde P, Leippold K, Armstrong A, Kohl S, Grimmer T, Diehl-Schmid J, Hermsdörfer J. Front Neurol. 2018 Aug 8;9:660. doi: 10.3389/fneur.2018.00660. eCollection 2018. PMID: 30135679 Free PMC article.

Plasma levels of soluble amyloid precursor protein β in symptomatic Alzheimer's disease. (link is external)

Alexopoulos P, Gleixner LS, Werle L, Buhl F, Thierjung N, Giourou E, Kagerbauer SM, Gourzis P, Kübler H, Grimmer T, Yakushev I, Martin J, Kurz A, Perneczky R. Eur Arch Psychiatry Clin Neurosci. 2018 Aug;268(5):519-524. doi: 10.1007/s00406-017-0815-9. Epub 2017 Jun 10. PMID: 28602012

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease. (link is external)

Mattsson N, Groot C, Jansen WJ, Landau SM, [...] Grimmer T et al. Alzheimers Dement. 2018 Jul;14(7):913-924. doi: 10.1016/j.jalz.2018.02.009. Epub 2018 Mar 28. PMID: 29601787

Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach. (link is external)

Begcevic I, Brinc D, Brown M, Martinez-Morillo E, Goldhardt O, Grimmer T, Magdolen V, Batruch I, Diamandis EP. J Proteomics. 2018 Jun 30;182:12-20. doi: 10.1016/j.jprot.2018.04.027. Epub 2018 Apr 22. PMID: 29684683

Sex Differences in Neuropsychological Test Performance in Alzheimer's Disease and the Influence of the ApoE Genotype. (link is external)

Tensil M, Hessler JB, Gutsmiedl M, Riedl L, Grimmer T, Diehl-Schmid J. Alzheimer Dis Assoc Disord. 2018 Apr-Jun;32(2):145-149. doi: 10.1097/WAD.0000000000000229. PMID: 29189302

Step by Step: Kinematics of the Reciprocal Trail Making Task Predict Slowness of Activities of Daily Living Performance in Alzheimer's Disease. (link is external)

Gulde P, Leippold K, Kohl S, Grimmer T, Diehl-Schmid J, Armstrong A, Hermsdörfer J. Front Neurol. 2018 Mar 14;9:140. doi: 10.3389/fneur.2018.00140. eCollection 2018.  PMID: 29593639 Free PMC article.

Fluid biomarker agreement and interrelation in dementia due to Alzheimer's disease. (link is external)

Alexopoulos P, Roesler J, Werle L, Thierjung N, Lentzari I, Ortner M, Grimmer T, Laskaris N, Politis A, Gourzis P, Kurz A, Perneczky R; Alzheimer’s Disease Neuroimaging        Initiative. J Neural Transm (Vienna). 2018 Feb;125(2):193-201. doi: 10.1007/s00702-017-1810-z. Epub 2017 Nov 15. PMID: 29143217

Cognitive Impairment is Associated with Mortality in Hemodialysis Patients. (link is external)

Angermann S, Schier J, Baumann M, Steubl D, Hauser C, Lorenz G, Günthner R, Braunisch MC, Kemmner S, Satanovskij R, Haller B, Heemann U, Lehnert T, Bieber R,      Pachmann M, Braun J, Scherf J, Schätzle G, Fischereder M, Grimmer T, Schmaderer C. J Alzheimers Dis. 2018;66(4):1529-1537. doi: 10.3233/JAD-180767. PMID: 30412499

Increasing Diagnostic Accuracy of Mild Cognitive Impairment due to Alzheimer's Disease by User-Independent, Web-Based Whole-Brain Volumetry. (link is external)

Hedderich DM, Spiro JE, Goldhardt O, Kaesmacher J, Wiestler B, Yakushev I, Zimmer C, Boeckh-Behrens T, Grimmer T. J Alzheimers Dis. 2018;65(4):1459-1467. doi: 10.3233/JAD-180532. PMID: 30175976

Cerebrospinal Fluid BACE1 Activity and sAβPPβ as Biomarker Candidates of Alzheimer's Disease. (link is external)

Alexopoulos P, Thierjung N, Grimmer T, Ortner M, Economou P, Assimakopoulos K, Gourzis P, Politis A, Perneczky R; The Alzheimer’s Disease Neuroimaging Initiative. Dement Geriatr Cogn Disord. 2018;45(3-4):152-161. doi: 10.1159/000488481. Epub 2018 May 22. PMID: 29788013 Free article.

2017

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia. (link is external)

Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, [...] Grimmer T  et al. JAMA Psychiatry. 2018 Jan 1;75(1):84-95. doi: 10.1001/jamapsychiatry.2017.3391. PMID: 29188296